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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cingulin-like 1 ： ウィキペディア英語版 Cingulin-like 1 Cingulin-like 1, also known as paracingulin or junction-associated-coiled-coil protein (JACOP), is a protein which is encoded by the ''CGNL1'' gene. The paracingulin polypeptide comprises a globular N-terminal "head" domain and an α-helical C-terminal domain which is presumed to form a coiled-coil dimer. Paracingulin is a paralog of cingulin that arose probably from gene duplication. The CGNL1 gene is conserved among different vertebrate species and has not been so far identified in invertebrates.〔〔 The homology search highlights that paracingulin and cingulin have 39% identity in the rod tail sequences. They possess also two highly homologous regions in their N-terminus “head” domain including the ZIM region (ZO-1 interaction motif).〔 The etymology of the name cingulin comes from the Latin "cingere" which means « to form a belt around ». Both, cingulin and paracingulin are localized in the cytoplasmic face of tight junctions (TJ).〔 The prefix « para » refers to “paralog”. However, immunoelectron microscopy indicates that paracingulin is not only localized in the TJ but also in the adherens junctions (AJ) depending on tissue type.〔 TJ and AJ together form the apical junctional complex (AJC) of vertebrate epithelial cells. The proteins present in this complex play a role in many cellular processes i.e., in the adhesion and barrier function of epithelia, the organization and dynamics of the cytoskeleton, as well as the regulation of Rho-GTPase family. ==Discovery== CGNL1 was originally discovered in 1997 as a 155 kDa protein localized at epithelial and endothelial cell-cell junctions by using a new monoclonal antibody produced through immunization with a cell-cell junction enriched in plasma membrane fraction from chick liver. Subsequently, cloning and sequencing of the CGNL1 gene identified the similarity to cingulin.〔〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cingulin-like 1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.